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Imatinib

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產(chǎn)品型號:152459-95-5

品       牌:medkoo

廠商性質(zhì):代理商

所  在  地:北京市

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更新時間:2023-07-12 09:38:34瀏覽次數(shù):880次

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CAS 152459-95-5 純度 >98%
分子量 493.615 分子式 C29H31N7O
供貨周期 現(xiàn)貨 規(guī)格 500mg,1g,5g,10g
貨號 152459-95-5 應(yīng)用領(lǐng)域 醫(yī)療衛(wèi)生,生物產(chǎn)業(yè),綜合
主要用途 科研
Imatinib is a tyrosine kinase inhibitor with antineoplastic activity. It binds to an intracellular pocket located within tyrosine kinases (TK).

Description: Imatinib is a tyrosine kinase inhibitor with antineoplastic activity. Imatinib binds to an intracellular pocket located within tyrosine kinases (TK), thereby inhibiting ATP binding and preventing phosphorylation and the subsequent activation of growth receptors and their downstream signal transduction pathways. This agent inhibits TK encoded by the bcr-abl oncogene as well as receptor TKs encoded by the c-kit and platelet-derived growth factor receptor (PDGFR) oncogenes. Imatinib was approved for medical use in the United States in 2001.

Name: Imatinib free base
CAS#: 152459-95-5 (free base)
Chemical Formula: C29H31N7O
Exact Mass: 493.259
Molecular Weight: 493.615
Elemental Analysis: C, 70.56; H, 6.33; N, 19.86; O, 3.24

Synonym: CGP 57148; CGP57148; CGP-57148; CGP57148B; CGP-57148B; CGP 57148B; STI571; STI-571; STI 571; Imatinib; US brand name: Gleevec. Foreign brand name: Glivec

IUPAC/Chemical Name: N-(4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)-4-((4-methylpiperazin-1-yl)methyl)benzamide

InChi Key: KTUFNOKKBVMGRW-UHFFFAOYSA-N

InChi Code: InChI=1S/C29H31N7O/c1-21-5-10-25(18-27(21)34-29-31-13-11-26(33-29)24-4-3-12-30-19-24)32-28(37)23-8-6-22(7-9-23)20-36-16-14-35(2)15-17-36/h3-13,18-19H,14-17,20H2,1-2H3,(H,32,37)(H,31,33,34)

SMILES Code: O=C(NC1=CC=C(C)C(NC2=NC=CC(C3=CC=CN=C3)=N2)=C1)C4=CC=C(CN5CCN(C)CC5)C=C4

Appearance: white to off-white to brownish or yellowish tinged crystalline powder.

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001





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